Is chemo painful?

Mu brother will begin his chemo in couple of weeks and he is so stressed about the pain waiting for him. Can anyone tell if the chemo for colon cancer is very painful? I don’t know his chemo regime yet, I just know that he has to take 4 pills a day (2 in the morning and 2 at night) plus infusion every 3 weeks. Please write about your experience that I can share with him and give him hope that it’s not very painful (hopefully)